TMPRSS5

Across TCGA cell cohorts, TMPRSS5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,363 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TMPRSS5-associated GO terms across cancer lineages are Positive regulation of intracellular estrogen receptor signaling pathway, Microtubule polymerization or depolymerization, and Microtubule polymerization. Each is linked with TMPRSS5 in more than 7 cancer types. Because this analysis shows association rather than direction, both TMPRSS5-to-partner and partner-to-TMPRSS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular estrogen receptor signaling pathway grouped by TMPRSS5-low versus TMPRSS5-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS5→partner) and Y-score (partner→TMPRSS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.208	+0.817	<.001	.006	3	8
BONE	Microtubule polymerization or depolymerization →	+0.153	+0.451	<.001	<.001	3	7
BONE	Microtubule polymerization →	+0.123	+0.521	<.001	.003	2	8
BONE	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.121	+0.694	<.001	.003	2	8
SOFT_TISSUE	Microtubule depolymerization →	+0.088	+0.202	.004	.007	3	7
BONE	Cell cycle G1/S phase transition →	+0.052	+0.558	.007	.009	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,363 associations by consensus.

Positive regulation of intracellular estrogen receptor signaling pathway by TMPRSS5 expression — BONE

Explore this box plot interactively →