TMPRSS4

Across TCGA pan-cancer cohorts, TMPRSS4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMPRSS4 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMPRSS4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMPRSS4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where TMPRSS4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.824	0.525	<.001	29	view →
LUAD	DFS	Tertile	All	0.686	0.907	.009	20	view →
LSCC	DFS	Median	II,III,IV	0.989	0.842	.027	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMPRSS4–HNSC (DFS)

Open the HNSC breakdown →