TMPRSS4

Across TCGA pan-cancer cohorts, TMPRSS4 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TMPRSS4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMPRSS4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TMPRSS4 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC, PDAC, and LSCC are the cancer types where TMPRSS4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMPRSS4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	−0.910	<.001	11	view →
PDAC	Female	III,IV	+2.035	<.001	10	view →
LSCC	Female	II,III,IV	+1.868	<.001	9	view →
LUAD	All	All	+0.295	.001	4	view →
COAD	All	II,III,IV	+0.148	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TMPRSS4–HNSC

Open the HNSC breakdown →