TMPRSS4

Across TCGA patient cohorts, TMPRSS4 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS4-associated genes across cancer lineages are EGFR, eIF4G, and ACVRL1. Each is linked with TMPRSS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS4-to-partner and partner-to-TMPRSS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by TMPRSS4-low versus TMPRSS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS4→partner) and Y-score (partner→TMPRSS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.237	-2.807	<.001	.003	3	1
UCEC	eIF4G →	+0.379	+2.807	.005	.003	3	1
UCEC	ACVRL1 →	-0.159	-2.439	.007	.019	3	1
UCEC	JNK2 →	+0.271	+2.115	.001	.019	3	1
UCEC	mTOR_pS2448 →	-0.178	-3.439	.006	.005	3	1
UCEC	Notch1 →	+0.218	+2.331	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

EGFR by TMPRSS4 expression — UCEC

Explore this box plot interactively →