TMPRSS3

Across TCGA patient cohorts, TMPRSS3 mutation is significantly associated with the RNA expression of many other genes, with 3,721 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS3-associated genes across cancer lineages are MIR668, ECI1, and CIDECP1. Each is linked with TMPRSS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMPRSS3-to-partner and partner-to-TMPRSS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR668 grouped by TMPRSS3-low versus TMPRSS3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS3→partner) and Y-score (partner→TMPRSS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR668 →	+0.136	+5.589	<.001	<.001	3	3
SKCM	ECI1 →	+0.411	+2.331	.005	.003	3	3
UCEC	CIDECP1 →	+0.416	+2.112	<.001	<.001	3	3
UCEC	NDUFS3 →	+0.275	+2.917	.002	<.001	3	3
UCEC	SLCO1B3 →	+0.687	+1.963	<.001	.002	3	3
SKCM	MRPL43 →	+0.365	+2.863	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,721 associations by consensus.

MIR668 by TMPRSS3 expression — CESC

Explore this box plot interactively →