TMPRSS3

Across TCGA patient cohorts, TMPRSS3 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS3-associated genes across cancer lineages are GATA6, Annexin-1, and Bim. Each is linked with TMPRSS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS3-to-partner and partner-to-TMPRSS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by TMPRSS3-low versus TMPRSS3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS3→partner) and Y-score (partner→TMPRSS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GATA6 →	-0.267	-3.444	.006	.004	3	2
UCEC	Annexin-1 →	+0.617	+2.827	<.001	.001	3	2
SKCM	Bim →	-0.243	-1.874	.019	.047	3	2
SKCM	c-Kit →	-0.677	-1.584	.008	.035	3	2
SKCM	E-Cadherin →	-0.809	-2.000	.017	.009	3	2
UCEC	eIF4E →	+0.169	+2.906	.018	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

GATA6 by TMPRSS3 expression — SKCM

Explore this box plot interactively →