TMPRSS3

Across TCGA cell cohorts, TMPRSS3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMPRSS3-associated genes across cancer lineages are OR8B12, OR8A1, and OR10D3. Each is linked with TMPRSS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS3-to-partner and partner-to-TMPRSS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B12 grouped by TMPRSS3-low versus TMPRSS3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS3→partner) and Y-score (partner→TMPRSS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR8B12 →	+0.086	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR8A1 →	+0.544	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR10D3 →	+0.119	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR8D2 →	+0.112	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR8B3 →	+0.036	+4.371	.002	.005	3	1
LUNG_NSCLC_LUAD	OR8B2 →	+0.097	+5.189	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR8B12 by TMPRSS3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →