Across TCGA pan-cancer cohorts, TMPRSS2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TMPRSS2 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TMPRSS2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMPRSS2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where TMPRSS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	IV	0.282	0.934	.024	12	view →
CCRCC	DFS	Quartile	All	1.000	0.519	.018	8	view →
HNSC	DFS	Median	All	0.934	0.497	.014	8	view →
UCEC	DFS	Tertile	All	0.948	0.695	.016	6	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.877	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TMPRSS2 tumor-vs-normal RNA expression · all TMPRSS2 data types