Across TCGA patient cohorts, TMPRSS2 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,906 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TMPRSS2-associated proteins across cancer lineages are SPTAN1_S1217, RBM47, and TJP3. Each is linked with TMPRSS2 in more than 5 cancer types. Because this analysis shows association rather than direction, both TMPRSS2-to-partner and partner-to-TMPRSS2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS2→partner) and Y-score (partner→TMPRSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SPTAN1_S1217 →	+0.413	+1.175	<.001	<.001	3	6
HNSC	RBM47 →	+0.323	+1.185	<.001	<.001	3	5
LSCC	TJP3 →	+0.428	+1.157	<.001	<.001	3	5
LSCC	TJP3_S112 →	+0.820	+1.466	<.001	<.001	3	5
LSCC	TJP3_S203 →	+0.717	+1.143	<.001	<.001	3	5
PDAC	TJP3_S346 →	+0.762	+1.202	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,906 associations by consensus.

Exploration

TMPRSS2 survival (RNA) · tumor vs normal (RNA) · all TMPRSS2 data types