Across TCGA patient cohorts, TMPRSS2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS2-associated genes across cancer lineages are PCNA, 4E-BP1, and Cyclin-B1. Each is linked with TMPRSS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS2-to-partner and partner-to-TMPRSS2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS2→partner) and Y-score (partner→TMPRSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.308	+1.807	<.001	.027	3	2
UCEC	4E-BP1 →	+0.435	+3.489	<.001	.002	3	2
UCEC	Cyclin-B1 →	+0.602	+3.459	.009	.005	3	2
SKCM	Src →	-0.326	-2.321	.004	.035	3	1
UCEC	FASN →	+0.459	+1.807	.004	.027	3	1
UCEC	GAPDH →	+0.614	+1.807	.005	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

TMPRSS2 survival (RNA) · tumor vs normal (RNA) · all TMPRSS2 data types