Across TCGA cell cohorts, TMPRSS2 RNA expression is significantly associated with the RNA expression of many other genes, with 9,039 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMPRSS2-associated genes across cancer lineages are TMEM45B, SLC37A1, and ELF3. Each is linked with TMPRSS2 in more than 10 cancer types. Because this analysis shows association rather than direction, both TMPRSS2-to-partner and partner-to-TMPRSS2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS2→partner) and Y-score (partner→TMPRSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TMEM45B →	+3.752	+2.991	<.001	<.001	3	11
URINARY_TRACT	SLC37A1 →	+2.455	+2.672	<.001	<.001	3	11
LUNG_NSCLC_LUAD	ELF3 →	+4.409	+2.663	<.001	<.001	3	11
STOMACH	TJP3 →	+2.662	+2.958	<.001	<.001	3	10
BREAST	STARD10 →	+3.076	+2.507	<.001	<.001	3	9
URINARY_TRACT	SMIM22 →	+4.603	+2.636	<.001	<.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,039 associations by consensus.

Exploration

TMPRSS2 survival (RNA) · tumor vs normal (RNA) · all TMPRSS2 data types