TMPRSS2

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, TMPRSS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,045 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMPRSS2-associated GO terms across cancer lineages are Cellular response to molecule of fungal origin, Secretion by tissue, and Response to molecule of fungal origin. Each is linked with TMPRSS2 in more than 9 cancer types. Because this analysis shows association rather than direction, both TMPRSS2-to-partner and partner-to-TMPRSS2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS2→partner) and Y-score (partner→TMPRSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
STOMACHCellular response to molecule of fungal origin →+1.425+3.103.002.00139
STOMACHSecretion by tissue →+0.334+3.247<.001<.00139
STOMACHResponse to molecule of fungal origin →+1.425+3.103.002.00139
STOMACHProtein transport into membrane raft →+0.624+3.165.003<.00139
STOMACHProtein transport within lipid bilayer →+0.503+3.155.002<.00138
URINARY_TRACTNegative regulation of mast cell degranulation →+1.834+2.846<.001<.00138
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,045 associations by consensus.

Exploration