TMPRSS15

Across TCGA patient cohorts, TMPRSS15 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,653 significant associations in total. THYM shows the largest number of these associations.

The most reproducible TMPRSS15-associated GO terms across cancer lineages are Regulation of protein serine/threonine kinase activity, Regulation of cyclin-dependent protein kinase activity, and Negative regulation of mitotic cell cycle. Each is linked with TMPRSS15 in more than 12 cancer types. Because this analysis shows association rather than direction, both TMPRSS15-to-partner and partner-to-TMPRSS15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein serine/threonine kinase activity grouped by TMPRSS15-low versus TMPRSS15-high in KIRC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS15→partner) and Y-score (partner→TMPRSS15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	Regulation of protein serine/threonine kinase activity →	+0.021	+0.068	<.001	.003	3	13
UCEC	Regulation of cyclin-dependent protein kinase activity →	+0.036	+0.208	<.001	<.001	3	13
LUSC	Negative regulation of mitotic cell cycle →	+0.027	+0.234	<.001	<.001	3	12
UCEC	Positive regulation of mitotic cell cycle →	+0.024	+0.114	<.001	<.001	3	12
UCEC	Positive regulation of establishment of protein localization to telomere →	+0.044	+0.188	<.001	<.001	3	12
KIRC	Protein folding →	+0.029	+0.054	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,653 associations by consensus.

Regulation of protein serine/threonine kinase activity by TMPRSS15 expression — KIRC

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