TMPRSS15

Across TCGA patient cohorts, TMPRSS15 mutation is significantly associated with the RNA expression of many other genes, with 5,515 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS15-associated genes across cancer lineages are HMGB1P32, GBP1P1, and ALMS1-IT1. Each is linked with TMPRSS15 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMPRSS15-to-partner and partner-to-TMPRSS15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P32 grouped by TMPRSS15-low versus TMPRSS15-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS15→partner) and Y-score (partner→TMPRSS15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	HMGB1P32 →	+0.059	+4.660	<.001	.005	3	3
UCEC	GBP1P1 →	+0.585	+2.425	.001	.001	3	3
LUSC	ALMS1-IT1 →	+0.454	+1.438	<.001	.006	3	3
SARC	LINC02791 →	+0.087	+4.954	<.001	.004	3	3
UCEC	ESS2 →	+0.238	+3.169	.001	<.001	3	3
UCEC	E2F1 →	+0.751	+1.747	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,515 associations by consensus.

HMGB1P32 by TMPRSS15 expression — LGG

Explore this box plot interactively →