TMPRSS15

Across TCGA cell cohorts, TMPRSS15 mutation is significantly associated with the RNA expression of many other genes, with 147 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMPRSS15-associated genes across cancer lineages are ODF1, USP17L17, and DPPA3. Each is linked with TMPRSS15 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS15-to-partner and partner-to-TMPRSS15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ODF1 grouped by TMPRSS15-low versus TMPRSS15-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS15→partner) and Y-score (partner→TMPRSS15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ODF1 →	+0.046	+2.681	.005	.008	3	2
SKIN	USP17L17 →	+0.005	+3.700	<.001	.009	3	2
BLOOD_Lymphoma	DPPA3 →	+0.007	+3.662	<.001	.009	3	2
BLOOD_Lymphoma	TBC1D28 →	+0.027	+2.807	.008	.005	3	2
BLOOD_Leukemia	RS1 →	+0.084	+3.564	.001	.003	3	2
BLOOD_Leukemia	EVPLL →	+0.499	+3.893	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 147 associations by consensus.

ODF1 by TMPRSS15 expression — BLOOD_Leukemia

Explore this box plot interactively →