TMPRSS13

Across TCGA cell cohorts, TMPRSS13 mutation is significantly associated with the mutation status of many other genes, with 2,737 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMPRSS13-associated genes across cancer lineages are SPTBN2, MAP3K10, and SPTAN1. Each is linked with TMPRSS13 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMPRSS13-to-partner and partner-to-TMPRSS13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPTBN2 grouped by TMPRSS13-low versus TMPRSS13-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS13→partner) and Y-score (partner→TMPRSS13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPTBN2 →	+3.193	+5.351	<.001	<.001	1	4
SOFT_TISSUE	MAP3K10 →	+5.502	+5.502	.003	.003	1	4
BONE	SPTAN1 →	+4.437	+5.000	.007	.007	1	3
BLOOD_Lymphoma	USP34 →	+3.584	+4.922	.001	.001	1	3
BLOOD_Lymphoma	WNK4 →	+5.169	+5.832	<.001	<.001	1	3
BLOOD_Lymphoma	ZBTB1 →	+6.169	+6.169	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,737 associations by consensus.

SPTBN2 by TMPRSS13 expression — BLOOD_Leukemia

Explore this box plot interactively →