Across TCGA pan-cancer cohorts, TMPRSS12 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMPRSS12 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher TMPRSS12 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMPRSS12 expression acts as an unfavorable survival marker.

KICH, LIHC, and UCEC are the cancer types where TMPRSS12 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LIHC	OS	Median	All	0.031	0.777	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TMPRSS12 tumor-vs-normal RNA expression · all TMPRSS12 data types