Across TCGA patient cohorts, TMPRSS12 mutation is significantly associated with the RNA expression of many other genes, with 1,407 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS12-associated genes across cancer lineages are ENPP7P3, OR1E3, and MIR1827. Each is linked with TMPRSS12 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMPRSS12-to-partner and partner-to-TMPRSS12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS12→partner) and Y-score (partner→TMPRSS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ENPP7P3 →	+0.205	+3.669	<.001	.006	3	3
LUAD	OR1E3 →	+0.058	+4.554	<.001	.009	3	2
LUAD	MIR1827 →	+0.808	+4.855	<.001	.002	3	2
UCEC	RNA5SP405 →	+0.208	+2.997	<.001	.006	3	2
UCEC	SNRPGP8 →	+0.110	+2.850	<.001	.002	3	2
UCEC	HSD17B7P1 →	+0.060	+1.978	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,407 associations by consensus.

Exploration

TMPRSS12 survival (RNA) · tumor vs normal (RNA) · all TMPRSS12 data types