TMPRSS12

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TMPRSS12 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS12-associated genes across cancer lineages are ATM, eIF4E, and ACC_pS79. Each is linked with TMPRSS12 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMPRSS12-to-partner and partner-to-TMPRSS12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS12→partner) and Y-score (partner→TMPRSS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECATM →-0.877-3.700<.001.00132
UCECeIF4E →+0.236+3.807.013<.00122
UCECACC_pS79 →+0.326+3.009.037.01931
UCECINPP4B →-0.413-3.459.004.00531
UCECJNK2 →+0.189+2.000.035.03231
UCECmTOR →-0.192-2.000.008.03231
Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration