Across TCGA pan-cancer cohorts, TMPRSS11A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TMPRSS11A data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMPRSS11A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated TMPRSS11A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LUSC, and ESCA are the cancer types where TMPRSS11A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.933	0.433	.015	18	view →
LUSC	OS	Median	III,IV	0.112	0.664	.003	12	view →
ESCA	DFS	Median	II,III,IV	0.201	0.525	.023	6	view →
READ	DFS	Median	IV	0.255	0.628	.020	3	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TMPRSS11A tumor-vs-normal RNA expression · all TMPRSS11A data types