TMPRSS11A

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TMPRSS11A mutation is significantly associated with the RNA expression of many other genes, with 1,596 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS11A-associated genes across cancer lineages are EMID1, RN7SL567P, and CENPH. Each is linked with TMPRSS11A in more than 2 cancer types. Because this analysis shows association rather than direction, both TMPRSS11A-to-partner and partner-to-TMPRSS11A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11A→partner) and Y-score (partner→TMPRSS11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMEMID1 →-0.850-3.284.002.00933
LUSCRN7SL567P →+0.180+4.678<.001.00133
UCECCENPH →+0.815+2.747<.001<.00132
UCECKCNJ15 →-0.751-2.967.005.00132
UCECSLC34A2 →-1.444-3.692<.001.00132
UCECZC3H18 →+0.456+2.345<.001.00332
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,596 associations by consensus.

Exploration