Across TCGA patient cohorts, TMPRSS11A mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS11A-associated genes across cancer lineages are Cyclin-B1, PAI-1, and PDCD4. Each is linked with TMPRSS11A in more than 2 cancer types. Because this analysis shows association rather than direction, both TMPRSS11A-to-partner and partner-to-TMPRSS11A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11A→partner) and Y-score (partner→TMPRSS11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.816	+3.459	<.001	.005	3	3
LUAD	PAI-1 →	+0.961	+3.000	.010	.036	3	2
LUAD	PDCD4 →	-0.685	-2.983	.002	.036	3	2
UCEC	FoxM1 →	+0.248	+2.999	.020	.035	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.488	+1.807	.020	.027	3	2
COAD	MIG-6 →	+0.107	+2.866	.048	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Exploration

TMPRSS11A survival (RNA) · tumor vs normal (RNA) · all TMPRSS11A data types