TMOD3

Across TCGA patient cohorts, TMOD3 mutation is significantly associated with the RNA expression of many other genes, with 2,100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMOD3-associated genes across cancer lineages are YWHAEP4, SNRPCP15, and MIR6894. Each is linked with TMOD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMOD3-to-partner and partner-to-TMOD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YWHAEP4 grouped by TMOD3-low versus TMOD3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMOD3→partner) and Y-score (partner→TMOD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	YWHAEP4 →	+0.152	+4.792	<.001	.006	3	2
SKCM	SNRPCP15 →	+0.202	+4.614	<.001	.006	3	2
BRCA	MIR6894 →	+0.541	+5.506	<.001	.005	3	1
BRCA	MIR6853 →	+0.242	+8.057	<.001	.005	3	1
BRCA	MIR7159 →	+0.476	+5.317	<.001	.006	3	1
BRCA	RNA5SP147 →	+0.329	+6.324	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,100 associations by consensus.

YWHAEP4 by TMOD3 expression — LUSC

Explore this box plot interactively →