TMOD3

Across TCGA patient cohorts, TMOD3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMOD3-associated genes across cancer lineages are GSK-3_pS9, mTOR_pS2448, and Notch1. Each is linked with TMOD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMOD3-to-partner and partner-to-TMOD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3_pS9 grouped by TMOD3-low versus TMOD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMOD3→partner) and Y-score (partner→TMOD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3_pS9 →	-0.351	-1.874	.035	.049	3	1
UCEC	mTOR_pS2448 →	-0.150	-2.302	.014	.034	3	1
UCEC	Notch1 →	+0.134	+2.331	.021	.019	3	1
UCEC	PCNA →	+0.289	+3.459	.001	.005	3	1
UCEC	Raptor →	-0.124	-2.321	.048	.034	3	1
UCEC	STAT3_pY705 →	-0.356	-2.574	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GSK-3_pS9 by TMOD3 expression — UCEC

Explore this box plot interactively →