TMOD2

Across TCGA patient cohorts, TMOD2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMOD2-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and Notch1. Each is linked with TMOD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMOD2-to-partner and partner-to-TMOD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TMOD2-low versus TMOD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMOD2→partner) and Y-score (partner→TMOD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.235	-1.678	.014	.023	3	2
UCEC	eIF4E →	+0.161	+1.750	.046	.049	3	2
UCEC	Notch1 →	+0.110	+1.678	.042	.023	3	2
UCEC	ASNS →	+0.567	+2.584	<.001	.010	3	2
UCEC	ERK2 →	+0.149	+1.678	.044	.023	3	1
UCEC	FOXO3a_pS318_S321 →	-0.125	-1.896	.009	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

EGFR_pY1068 by TMOD2 expression — UCEC

Explore this box plot interactively →