TMOD2

Across TCGA cell cohorts, TMOD2 mutation is significantly associated with the drug of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMOD2-associated genes across cancer lineages are Fludarabine, Sphingosine Kinase 1 Inhibitor II, and Ara-G. Each is linked with TMOD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMOD2-to-partner and partner-to-TMOD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fludarabine grouped by TMOD2-low versus TMOD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMOD2→partner) and Y-score (partner→TMOD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Fludarabine →	+0.534	+2.649	.045	.046	3	1
LARGE_INTESTINE	Sphingosine Kinase 1 Inhibitor II →	+0.278	+2.786	.013	.037	3	1
LARGE_INTESTINE	Ara-G →	+0.186	+2.722	.027	.040	3	1
LARGE_INTESTINE	Acetalax →	+0.692	+2.649	.036	.046	2	1
LARGE_INTESTINE	50869 →	+0.545	+2.678	.009	.037	2	1
LARGE_INTESTINE	150412 →	+0.401	+2.777	.016	.038	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Fludarabine by TMOD2 expression — LARGE_INTESTINE

Explore this box plot interactively →