TMIGD3

Across TCGA patient cohorts, TMIGD3 mutation is significantly associated with the RNA expression of many other genes, with 3,505 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMIGD3-associated genes across cancer lineages are NICN2P, MAPK1, and EIF5. Each is linked with TMIGD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMIGD3-to-partner and partner-to-TMIGD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NICN2P grouped by TMIGD3-low versus TMIGD3-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMIGD3→partner) and Y-score (partner→TMIGD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	NICN2P →	+0.087	+4.520	.001	.005	3	3
UCEC	MAPK1 →	+0.538	+2.354	<.001	.003	3	3
SKCM	EIF5 →	+0.542	+2.738	.003	.002	3	3
UCEC	PSMC1 →	+0.424	+2.928	.008	<.001	3	3
UCEC	SRP54 →	+0.465	+2.244	.001	<.001	3	3
SKCM	LACTB →	+0.651	+2.813	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,505 associations by consensus.

NICN2P by TMIGD3 expression — PRAD

Explore this box plot interactively →