TMIGD3

Across TCGA patient cohorts, TMIGD3 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMIGD3-associated genes across cancer lineages are PCNA, Myosin-IIa_pS1943, and Annexin-1. Each is linked with TMIGD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMIGD3-to-partner and partner-to-TMIGD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TMIGD3-low versus TMIGD3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMIGD3→partner) and Y-score (partner→TMIGD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.273	+2.815	.044	.036	3	2
SKCM	Myosin-IIa_pS1943 →	+0.243	+3.000	.035	.034	3	2
SKCM	Annexin-1 →	+0.540	+3.321	.004	.009	3	2
SKCM	c-Kit →	-0.575	-2.459	.032	.018	3	2
UCEC	eIF4G →	+0.281	+1.700	.016	.042	3	2
UCEC	mTOR_pS2448 →	-0.126	-2.095	.023	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PCNA by TMIGD3 expression — COAD

Explore this box plot interactively →