TMIGD2

Across TCGA patient cohorts, TMIGD2 mutation is significantly associated with the RNA expression of many other genes, with 1,050 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMIGD2-associated genes across cancer lineages are GPATCH11, AZI2, and TBC1D2B. Each is linked with TMIGD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMIGD2-to-partner and partner-to-TMIGD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPATCH11 grouped by TMIGD2-low versus TMIGD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMIGD2→partner) and Y-score (partner→TMIGD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPATCH11 →	+0.532	+2.595	.002	.006	3	2
UCEC	AZI2 →	+0.536	+3.210	.006	.009	3	2
UCEC	TBC1D2B →	+0.544	+2.606	.003	.006	3	2
UCEC	CWF19L1 →	+0.465	+2.606	.002	.006	3	2
UCEC	POMT2 →	+0.554	+3.338	<.001	.005	3	2
LUAD	TIMM8BP1 →	+0.166	+4.984	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,050 associations by consensus.

GPATCH11 by TMIGD2 expression — UCEC

Explore this box plot interactively →