TMIGD1

Across TCGA patient cohorts, TMIGD1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMIGD1-associated genes across cancer lineages are Chk2, Caspase-8, and JNK2. Each is linked with TMIGD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMIGD1-to-partner and partner-to-TMIGD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2 grouped by TMIGD1-low versus TMIGD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMIGD1→partner) and Y-score (partner→TMIGD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2 →	-0.255	-3.169	.047	.020	3	2
UCEC	Caspase-8 →	-0.314	-3.000	.023	.036	2	1
UCEC	JNK2 →	+0.232	+3.169	.033	.020	1	1
UCEC	VHL →	-1.327	-3.169	<.001	.020	1	1
UCEC	ATM →	-0.517	-3.169	.038	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Chk2 by TMIGD1 expression — UCEC

Explore this box plot interactively →