TMIE

Across TCGA patient cohorts, TMIE protein abundance is significantly associated with the RNA expression of many other genes, with 64 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMIE-associated genes across cancer lineages are DKKL1, OPN4, and RGS22. Each is linked with TMIE in more than 1 cancer types. Because this analysis shows association rather than direction, both TMIE-to-partner and partner-to-TMIE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMIE versus DKKL1 in GBM, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMIE→partner) and Y-score (partner→TMIE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DKKL1 →	+0.508	+0.793	.006	.001	3	1
GBM	OPN4 →	+0.191	+0.930	<.001	<.001	3	1
GBM	RGS22 →	+2.211	+0.968	.002	.007	3	1
GBM	ZDHHC8P1 →	+1.290	+0.959	.003	.007	3	1
GBM	SLC27A3 →	+0.531	+0.811	.001	.006	3	1
GBM	IL20RA →	+1.216	+0.994	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

TMIE vs DKKL1 — GBM

Explore this scatter interactively →