TMIE

Across TCGA cell cohorts, TMIE RNA expression is significantly associated with the go_rna of many other GO terms, with 1,812 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMIE-associated GO terms across cancer lineages are Regulation of proteasomal protein catabolic process, Complement-mediated synapse pruning, and Cellular response to unfolded protein. Each is linked with TMIE in more than 8 cancer types. Because this analysis shows association rather than direction, both TMIE-to-partner and partner-to-TMIE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of proteasomal protein catabolic process grouped by TMIE-low versus TMIE-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMIE→partner) and Y-score (partner→TMIE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of proteasomal protein catabolic process →	+0.056	+0.509	<.001	.009	3	9
PANCREAS	Complement-mediated synapse pruning →	+1.265	+0.840	.001	.002	3	7
OESOPHAGUS	Cellular response to unfolded protein →	+0.072	+0.679	.006	.005	3	7
STOMACH	Regulation of response to endoplasmic reticulum stress →	+0.073	+0.397	<.001	.001	3	7
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cell-substrate adhesion →	+0.074	+0.364	.001	.007	3	7
UPPER_AERODIGESTIVE_TRACT	Positive regulation of protein catabolic process →	+0.033	+0.360	.009	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,812 associations by consensus.

Regulation of proteasomal protein catabolic process by TMIE expression — LUNG_SCLC

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