TMEM9B

Across TCGA pan-cancer cohorts, TMEM9B RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TMEM9B data layer compared with 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM9B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM9B expression acts as an unfavorable survival marker, although some lineages such as THCA and MESO show a favorable association.

HNSC, UVM, and THCA are the cancer types where TMEM9B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.415	0.726	.002	70	view →
UVM	OS	Median	II,III,IV	0.750	0.933	.007	58	view →
THCA	DFS	Median	All	0.892	0.760	<.001	40	view →
MESO	OS	Quartile	All	0.574	0.286	.005	33	view →
ACC	DFS	Quartile	All	0.310	0.695	.013	24	view →
UCS	DFS	Tertile	IV	0.821	0.239	.024	24	view →
KIRC	OS	Median	All	0.695	0.535	.005	24	view →
PAAD	DFS	Median	All	0.360	0.567	.003	23	view →
LIHC	OS	Quartile	All	0.625	0.789	.007	20	view →
SCLC	OS	Median	All	0.488	0.935	.007	19	view →
LAML	DFS	Quartile	All	0.286	0.674	.007	18	view →
KIRP	DFS	Median	IV	0.039	0.526	.027	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TMEM9B–HNSC (OS)

Open the HNSC breakdown →