TMEM99

Across TCGA cell cohorts, TMEM99 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,330 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM99-associated GO terms across cancer lineages are Cornification, Attachment of GPI anchor to protein, and Azole transmembrane transport. Each is linked with TMEM99 in more than 8 cancer types. Because this analysis shows association rather than direction, both TMEM99-to-partner and partner-to-TMEM99 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cornification grouped by TMEM99-low versus TMEM99-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM99→partner) and Y-score (partner→TMEM99) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cornification →	+0.554	+1.110	.007	<.001	3	9
SOFT_TISSUE	Attachment of GPI anchor to protein →	+0.151	+1.001	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Azole transmembrane transport →	-0.151	-0.953	<.001	<.001	3	7
PANCREAS	Cytoplasmic translation →	+0.061	+0.676	<.001	.002	3	6
LUNG_SCLC	Protein heterotetramerization →	+0.142	+1.605	<.001	<.001	3	6
LARGE_INTESTINE	Regulation of transmembrane transporter activity →	-0.074	-1.107	.005	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,330 associations by consensus.

Cornification by TMEM99 expression — LUNG_SCLC

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