TMEM98

Across TCGA patient cohorts, TMEM98 mutation is significantly associated with the RNA expression of many other genes, with 882 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM98-associated genes across cancer lineages are RNA5SP417, RNA5SP422, and RNA5SP412. Each is linked with TMEM98 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM98-to-partner and partner-to-TMEM98 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP417 grouped by TMEM98-low versus TMEM98-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM98→partner) and Y-score (partner→TMEM98) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP417 →	+0.617	+2.614	<.001	.001	3	2
UCEC	RNA5SP422 →	+0.752	+2.308	<.001	.002	3	2
UCEC	RNA5SP412 →	+0.551	+2.230	.001	.005	3	2
UCEC	MFSD12 →	+0.568	+2.839	.001	.001	3	2
UCEC	KLHL30-AS1 →	+0.214	+3.241	.004	.009	3	1
UCEC	LINC01943 →	+0.432	+3.212	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 882 associations by consensus.

RNA5SP417 by TMEM98 expression — UCEC

Explore this box plot interactively →