TMEM8B

Across TCGA patient cohorts, TMEM8B RNA expression is significantly associated with the protein abundance of many other proteins, with 20,509 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM8B-associated proteins across cancer lineages are CGAS, AGO1, and ICAM1. Each is linked with TMEM8B in more than 5 cancer types. Because this analysis shows association rather than direction, both TMEM8B-to-partner and partner-to-TMEM8B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM8B versus CGAS in UCEC, with a Pearson correlation of -0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM8B→partner) and Y-score (partner→TMEM8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CGAS →	-0.514	-0.484	<.001	<.001	3	6
LUAD	AGO1 →	+0.263	+0.562	<.001	<.001	3	6
BRCA	ICAM1 →	-0.543	-0.663	.001	<.001	3	6
LUAD	NOP2 →	-0.512	-0.619	<.001	<.001	3	6
CCRCC	NRBF2 →	-0.495	-0.444	<.001	<.001	3	6
PDAC	AZU1 →	-0.824	-0.604	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,509 associations by consensus.

TMEM8B vs CGAS — UCEC

Explore this scatter interactively →