TMEM8B

Across TCGA patient cohorts, TMEM8B protein abundance is significantly associated with the RNA expression of many other genes, with 2,050 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM8B-associated genes across cancer lineages are ZC3H12C, CTNND2, and ZNF816. Each is linked with TMEM8B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM8B-to-partner and partner-to-TMEM8B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM8B versus ZC3H12C in HNSC, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM8B→partner) and Y-score (partner→TMEM8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZC3H12C →	+0.879	+0.402	.001	<.001	3	2
PDAC	CTNND2 →	+1.037	+0.310	<.001	<.001	3	2
PDAC	ZNF816 →	-0.622	-0.410	.004	.002	3	2
BRCA	ROCR →	+2.208	+0.627	.004	.009	3	2
PDAC	RPP40P2 →	+0.552	+0.270	.001	.001	3	2
BRCA	CDH3 →	+2.414	+0.677	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,050 associations by consensus.

TMEM8B vs ZC3H12C — HNSC

Explore this scatter interactively →