TMEM8B

Across TCGA patient cohorts, TMEM8B mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM8B-associated genes across cancer lineages are VEGFR2, ATM, and IRS1. Each is linked with TMEM8B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM8B-to-partner and partner-to-TMEM8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VEGFR2 grouped by TMEM8B-low versus TMEM8B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM8B→partner) and Y-score (partner→TMEM8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VEGFR2 →	+0.225	+1.331	.029	.043	3	2
UCEC	ATM →	-0.520	-2.459	<.001	<.001	3	2
UCEC	IRS1 →	+0.188	+1.440	.008	.024	3	1
UCEC	JNK2 →	+0.209	+1.687	.002	.013	3	1
UCEC	MEK1 →	+0.366	+2.700	.003	.005	3	1
UCEC	Notch1 →	+0.200	+3.710	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

VEGFR2 by TMEM8B expression — UCEC

Explore this box plot interactively →