TMEM8B

Across TCGA cell cohorts, TMEM8B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,722 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM8B-associated GO terms across cancer lineages are Regulation of macroautophagy, Positive regulation of autophagy, and Macroautophagy. Each is linked with TMEM8B in more than 14 cancer types. Because this analysis shows association rather than direction, both TMEM8B-to-partner and partner-to-TMEM8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macroautophagy grouped by TMEM8B-low versus TMEM8B-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM8B→partner) and Y-score (partner→TMEM8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of macroautophagy →	+0.082	+1.138	<.001	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of autophagy →	+0.054	+0.941	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.082	+1.413	<.001	<.001	3	14
STOMACH	Negative regulation of myoblast fusion →	+0.139	+1.042	.001	.003	3	14
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.135	+1.130	.002	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.107	-1.096	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,722 associations by consensus.

Regulation of macroautophagy by TMEM8B expression — OESOPHAGUS

Explore this box plot interactively →