TMEM8B

Across TCGA cell cohorts, TMEM8B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TMEM8B-associated genes across cancer lineages are TRIM60, KRTAP4-12, and KRTAP10-4. Each is linked with TMEM8B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM8B-to-partner and partner-to-TMEM8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM60 grouped by TMEM8B-low versus TMEM8B-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM8B→partner) and Y-score (partner→TMEM8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TRIM60 →	+0.345	+4.867	<.001	.009	3	1
BREAST	KRTAP4-12 →	+0.035	+4.781	<.001	.003	3	1
BREAST	KRTAP10-4 →	+0.041	+4.672	<.001	.002	3	1
LUNG_SCLC	OR5T2 →	+0.020	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TRIM60 by TMEM8B expression — BLOOD_Lymphoma

Explore this box plot interactively →