Across TCGA patient cohorts, TMEM89 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM89-associated genes across cancer lineages are ARL2BPP6, RNU6-383P, and NPM1P17. Each is linked with TMEM89 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM89-to-partner and partner-to-TMEM89 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM89→partner) and Y-score (partner→TMEM89) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ARL2BPP6 →	+0.087	+4.454	<.001	.002	3	2
UCEC	RNU6-383P →	+0.629	+4.132	<.001	.009	3	2
UCEC	NPM1P17 →	+0.174	+3.474	<.001	.006	3	2
UCEC	MTCO1P35 →	+0.300	+4.206	.007	.001	3	2
SKCM	LINC02530 →	+0.042	+4.208	<.001	.003	3	1
SKCM	GAPDHP19 →	+0.048	+4.739	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

Exploration

TMEM89 survival (RNA) · tumor vs normal (RNA) · all TMEM89 data types