TMEM88

Across TCGA patient cohorts, TMEM88 mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM88-associated genes across cancer lineages are RN7SL98P, IGHD1-20, and RNU6-492P. Each is linked with TMEM88 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM88-to-partner and partner-to-TMEM88 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL98P grouped by TMEM88-low versus TMEM88-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM88→partner) and Y-score (partner→TMEM88) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL98P →	+0.264	+5.693	.001	.003	3	2
UCEC	IGHD1-20 →	+0.651	+4.137	<.001	.008	3	2
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	1
HNSC	MIR764 →	+0.578	+7.954	<.001	.008	3	1
HNSC	RNU4-26P →	+0.268	+7.954	<.001	.008	3	1
UCEC	RN7SL386P →	+0.185	+3.599	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

RN7SL98P by TMEM88 expression — COAD

Explore this box plot interactively →