TMEM87A

Across TCGA patient cohorts, TMEM87A mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM87A-associated genes across cancer lineages are Smad3, eEF2, and A-Raf_pS299. Each is linked with TMEM87A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM87A-to-partner and partner-to-TMEM87A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad3 grouped by TMEM87A-low versus TMEM87A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM87A→partner) and Y-score (partner→TMEM87A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Smad3 →	+0.165	+3.321	.007	.009	3	2
UCEC	eEF2 →	+0.416	+3.321	.004	.009	3	1
UCEC	A-Raf_pS299 →	-0.162	-3.169	.001	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.138	-2.212	.007	.010	3	1
UCEC	GAPDH →	+0.486	+1.807	.028	.027	3	1
UCEC	GATA6 →	-0.125	-1.800	.049	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Smad3 by TMEM87A expression — UCEC

Explore this box plot interactively →