TMEM86A

Across TCGA pan-cancer cohorts, TMEM86A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM86A data layer compared with 21 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher TMEM86A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM86A expression acts as an unfavorable survival marker.

LGG, PRAD, and UCEC are the cancer types where TMEM86A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.110	0.832	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM86A–LGG (DFS)

Open the LGG breakdown →