TMEM86A

Across TCGA patient cohorts, TMEM86A protein abundance is significantly associated with the RNA expression of many other genes, with 734 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TMEM86A-associated genes across cancer lineages are CNN3, SPECC1, and GUCY1A2. Each is linked with TMEM86A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM86A-to-partner and partner-to-TMEM86A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM86A versus CNN3 in BRCA, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM86A→partner) and Y-score (partner→TMEM86A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNN3 →	+1.167	+0.976	<.001	.002	3	2
BRCA	SPECC1 →	+1.021	+1.189	.007	.007	3	2
BRCA	GUCY1A2 →	+0.870	+1.022	.003	.008	3	2
BRCA	CCDC152 →	+0.960	+1.567	.002	.006	3	2
BRCA	HECW2-AS1 →	+2.285	+1.497	.007	.007	3	2
BRCA	ARHGEF38 →	+2.429	+1.680	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 734 associations by consensus.

TMEM86A vs CNN3 — BRCA

Explore this scatter interactively →