TMEM86A

Across TCGA patient cohorts, TMEM86A mutation is significantly associated with the RNA expression of many other genes, with 1,889 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM86A-associated genes across cancer lineages are APOOP2, RNA5SP417, and RNA5SP423. Each is linked with TMEM86A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM86A-to-partner and partner-to-TMEM86A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOOP2 grouped by TMEM86A-low versus TMEM86A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM86A→partner) and Y-score (partner→TMEM86A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	APOOP2 →	+0.404	+5.090	<.001	.001	3	2
UCEC	RNA5SP417 →	+0.452	+2.071	<.001	.003	3	2
UCEC	RNA5SP423 →	+0.607	+1.980	<.001	.001	3	2
COAD	RPS19P6 →	+0.588	+5.080	<.001	.008	3	2
UCEC	DPRXP2 →	+0.227	+1.898	.004	.009	3	1
UCEC	IRF2-DT →	-0.388	-2.300	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,889 associations by consensus.

APOOP2 by TMEM86A expression — STAD

Explore this box plot interactively →