TMEM86A

Across TCGA patient cohorts, TMEM86A mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM86A-associated genes across cancer lineages are Notch1, eEF2, and A-Raf_pS299. Each is linked with TMEM86A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM86A-to-partner and partner-to-TMEM86A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TMEM86A-low versus TMEM86A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM86A→partner) and Y-score (partner→TMEM86A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.211	+2.087	<.001	.005	3	2
UCEC	eEF2 →	+0.296	+2.321	.031	.034	3	1
UCEC	A-Raf_pS299 →	-0.146	-3.321	.001	.010	3	1
UCEC	GATA6 →	-0.134	-2.000	.023	.030	3	1
UCEC	Heregulin →	-0.114	-1.700	.016	.042	3	1
UCEC	INPP4B →	-0.357	-3.906	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Notch1 by TMEM86A expression — UCEC

Explore this box plot interactively →