TMEM82

Across TCGA cell cohorts, TMEM82 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TMEM82-associated genes across cancer lineages are MMP27, RTP1, and COX4I2. Each is linked with TMEM82 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM82-to-partner and partner-to-TMEM82 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP27 grouped by TMEM82-low versus TMEM82-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM82→partner) and Y-score (partner→TMEM82) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MMP27 →	+0.057	+4.415	<.001	.001	3	1
SKIN	RTP1 →	+0.010	+4.196	<.001	.002	3	1
LUNG_NSCLC_LUAD	COX4I2 →	+0.095	+5.228	<.001	.005	3	1
LUNG_SCLC	OR12D3 →	+0.004	+4.058	<.001	.007	3	1
LUNG_SCLC	CRYGB →	+0.050	+4.058	<.001	.007	3	1
LUNG_SCLC	SRY →	+0.250	+3.817	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MMP27 by TMEM82 expression — SKIN

Explore this box plot interactively →