TMEM81

Across TCGA patient cohorts, TMEM81 mutation is significantly associated with the RNA expression of many other genes, with 760 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM81-associated genes across cancer lineages are IDH2-DT, NOLC1P1, and MIR3678. Each is linked with TMEM81 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM81-to-partner and partner-to-TMEM81 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IDH2-DT grouped by TMEM81-low versus TMEM81-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM81→partner) and Y-score (partner→TMEM81) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	IDH2-DT →	+0.132	+3.404	.009	.001	3	2
LUAD	NOLC1P1 →	+0.035	+3.445	<.001	.006	3	2
LUAD	MIR3678 →	+0.312	+4.984	<.001	<.001	3	2
UCEC	UBAP1L →	+0.437	+2.765	<.001	.002	3	2
UCEC	LIN7C →	+0.692	+3.467	.001	.002	3	1
UCEC	PTPRJ →	+0.760	+3.343	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 760 associations by consensus.

IDH2-DT by TMEM81 expression — SKCM

Explore this box plot interactively →