TMEM81

Across TCGA patient cohorts, TMEM81 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM81-associated genes across cancer lineages are Caveolin-1, Ku80, and 4E-BP1. Each is linked with TMEM81 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM81-to-partner and partner-to-TMEM81 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by TMEM81-low versus TMEM81-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM81→partner) and Y-score (partner→TMEM81) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caveolin-1 →	-0.855	-2.459	.014	.020	3	2
UCEC	Ku80 →	+0.257	+2.472	.024	.011	3	1
UCEC	4E-BP1 →	+0.335	+3.199	.010	.009	2	2
UCEC	eIF4G →	+0.370	+3.000	.013	.036	2	1
UCEC	Notch1 →	+0.215	+2.817	.001	.036	2	1
UCEC	P-Cadherin →	-0.204	-3.159	.003	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Caveolin-1 by TMEM81 expression — UCEC

Explore this box plot interactively →